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From Atlanta/Gadsden/Airport
• Follow I-20 West (from Atlanta) or I-59 South (from Gadsden) into Birmingham (from airport, take I-59 South into Birmingham)
• I-20 and I-59 will merge just before downtown - follow I-20 West / I-59 South into downtown
• Exit at 22nd Street exit ; 22nd is one-way to the South
• Follow 22nd Street to 4th Avenue North (approx. 5 blocks)
• Turn right (West) on 4th Avenue North (one-way to the right)
• Go four blocks to 18th Street and turn right
• Go one block to 5th Avenue North and turn right
• One Federal Place is on 5th Avenue North between 18th and 19th Street

From Tuscaloosa/Bessemer
• Follow I-20 East / I-59 North into Birmingham
• Exit at 22nd Street exit ; 22nd is one-way to the South
• Follow 22nd Street to 4th Avenue North (approx. 5 blocks)
• Turn right (West) on 4th Avenue North (one-way to the right)
• Go four blocks to 18th Street and turn right
• Go one block to 5th Avenue North and turn right
• One Federal Place is on 5th Avenue North between 18th and 19th Street

From Nashville
• Follow I-65 South into Birmingham
• At I-20 / I-59 junction, take I-20 East / I-59 North into downtown Birmingham
• Exit at 22nd Street exit ; 22nd is one-way to the South
• Follow 22nd Street to 4th Avenue North (approx. 5 blocks)
• Turn right (West) on 4th Avenue North (one-way to the right)
• Go four blocks to 18th Street and turn right
• Go one block to 5th Avenue North and turn right
• One Federal Place is on 5th Avenue North between 18th and 19th Street

From Montgomery
• Follow I-65 North to Birmingham
• Exit at 3rd Avenue North ; 3rd is one-way to the East
• Follow 3rd Avenue to 18th Street and turn left
• Go one block to 5th Avenue North and turn right
• One Federal Place is on 5th Avenue North between 18th and 19th Street

From Inverness/Hoover/Homewood
• Follow Hwy 280 West (from Inverness) to Hwy 31 North
• Follow Hwy 31 North (from Hoover/Homewood) to Birmingham
• Follow Hwy 31 North into downtown Birmingham
• Exit at 2nd Avenue North ; 2nd is one-way to the West
• Follow 2nd Avenue to 18th Street and turn right
• Go three blocks to 5th Avenue North and turn right
• One Federal Place is on 5th Avenue North between 18th and 19th Street